Development of Discriminatory Method for Dissolution of Carvedilol Marketed Formulations

Carvedilol (BCS Class II drug) is a nonselective β-adrenergic blocking agent with α1-blocking activity and it is mainly used in the management of hypertension. Two commercial brands of carvedilol drug, of strength 12.5mg were used for the Invitro dissolution studies. In the present study four dissolution media [pH 1.2 (0.1 N Hcl), pH 4.5 Acetate buffer, pH 6.8 phosphate buffer, and Distilled water] with different agitation speeds (50, 75 and 100 rpm) were employed. An agitation speed of 100 rpm showed more drug release profile than 50 and 75 rpm. The dissolution rate was found to be influenced by the dissolution medium and paddle speed. The dissolution studies conducted with water in presence of paddle set at 50 rpm is more suitable for discrimination of marketed formulations of Carvedilol.